Harvard Medical School Post-Doctoral researcher (2006.11-2008.12)
Harvard Medical School Visiting Fellow Scientist (2009.01-현재)
CHA Univ. Clinical Statistics Center Director (2009.01-2016.12)
Seoul CRO, Statistics Department, Director (2009.10~2015.12)
CHA Univ. Dep. of Biotechnology Associate professor (2009.01-현재)
CHA Univ. Anti-aging Center Director (2011.01-현재)
CHA Univ. Dep. of Biotechnology 학과장 (2017.12-2019.03)
CHA Univ. Global Center, Director (2019.03-현재)
CHA Group Research Center, NPC Center, Director (2018.12~현재)
CHA Bio Tech, NPC Research Center, Director (2015.01~현재)
차의과학대학교 글로벌교류센터 센터장
[대외활동]
충남도 바이오융합산업 특별위원회, 위원
미세먼지 학회, 학회임원
논문
[프로젝트]
치매진단기기 개발
노화진단기기 개발
파킨슨치료제 개발
치매치료제 개발
[주요연구내용]
태아 중뇌유래 신경전구세포 이용 신경질환 치료제 개발
태반 유래 줄기세포를 이용한 항노화 및 신경질환 치료제 개발
Bioinformatics and Statistics
[논문 국외 (최근 5년간)]
HIF1-α-Mediated AIMP3 suppression delays stem cell aging via the induction of autophagy. Aging Cell. 2019 (IF 7.627)
Bioassay for monitoring the anti-aging effect of cord blood treatment. Theranostics. 2019 (IF 8.537)
Respiratory Toxicity of Polyhexamethylene Guanidine Phosphate Exposure in Zebrafish. Zebrafish. 2018 (IF 1.733)
Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods. Yonsei Medical Journal. 2018 (IF 1.564)
Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease. Cell Transplantation. 2018 (IF 2.885)
Decipher reliable biomarkers of brain aging by integrating literaturebased evidence with interactome data. Experimental and Molecular Medicine. 2018 (IF 5.584)
Immune-modulatory effect of CD200-positive human placenta-derived stem cells in the early phase of stroke. Experimental and Molecular Medicine. 2018 (IF 5.584)
Double-Injected Human Stem Cells Enhance Rehabilitation in TBI Mice Via Modulation of Survival and Inflammation. Molecular Neurobiology. 2018 (IF 5.076)
Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway. Molecular Neurobiology. 2018 (IF 5.076)
Preclinical Analysis of Fetal Human Mesencephalic Neural Progenitor Cell Lines: Characterization and Safety in-vitro and in-vivo. Stem Cells Translational Medicine. 2017 (IF 4.929)
Retinal Angiogenesis Effects of TGF-β1 and Paracrine Factors Secreted From Human Placental Stem Cells in Response to a Pathological Environment. Cell Transplantation. 2016 (IF 3.006)
Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease. Proc Natl Acad Sci U S A. 2015 (IF 9.423)
Effects of TGF-β1 and paracrine factors secreted from human placenta stem cells in response to a pathologic environment on retinal angiogenesis. Cell Transplant. 2015 (IF 3.427)
Functional analysis of the molecular interactions of TATA box containing genes and essential genes. PLOS ONE. 2015 (IF 3.057)
Improvement of neurological dysfunctions in aphakia mice, a model of Parkinson’s disease, after transplantation of ES cell-derived dopaminergic neuronal precursors. Methods Mol Biol. 2014
Correlation between Expression of Glucose Transporters in Granulosa Cells and Oocyte Quality in Women with Polycystic Ovary Syndrome. Endocrinol Metab (Seoul). 2014
Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks. Nucleic Acids Research. 2013
Long-term Immunomodulatory Effect of Amniotic Stem Cells in Alzheimer’s Disease Model. Neurobiology of Aging. 2013
Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson’s disease, the aphakia mouse. Cell Transplant. 2013.
Isolation and characterization of novel, highly proliferative human CD34/CD73-double positive testis-derived stem cells (HTSC) for cell therapy. Stem Cells Dev. 2013.
“Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers. Apoptosis. 2013.
Assessment of Early Phase -FP-CIT PET as an Alternative Method of FDG PET for Voxel Based Statistical Analysis: Application for Parkinson’s Disease Rat Model. IEEE TNS. 2013.”
The Effect of Attenuation and Scatter Correction Rat Brain PET. IEEE TNS. 2013.
Genome-wide characterization of the relationship between essential and TATA-containing genes. FEBS LETTERS. 2013
Neuronal properties, in vivo effects, and pathology of a Huntington’s disease patient-derived induced pluripotent stem cells. Stem Cells. 2012
The Levels of Pro-Inflammatory Factors Are Significantly Decreased in Cerebral Palsy Patients Following an Allogeneic Umbilical Cord Blood Cell Transplant. International Journal of Stem Cells. 20122
Long-lasting paracrine effects of human cord blood cells (hUCBCs) on damaged neocortex in an animal model of cerebral palsy. Cell Transplant. 2012
Expression of interferon regulatory factor-1 in the mouse cumulus-oocyte complex is negatively related with oocyte maturation. Clin Exp Reprod Med. 2011
Anti-fibrotic effect of chorionic plate-derived mesenchymal stem cells isolated from human placenta in a rat model of CCl(4)-injured liver: potential application to the treatment of hepatic diseases. J Cell Biochem. 2010
Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome. Behav Neurosci. 2010.
Obox4 critically regulates cAMP-dependent meiotic arrest and MI-MII transition in oocytes FASEB J. 2010
Essential role for TRPC5 in amygdale function and fear-related behavior. Cell. 2009
Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson’s disease. Neurobiol Dis. 2008
A mouse model of fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies. Dev Psychobiol. 2008
Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome. Behav Neurosci. 2008
Evidence for impairments in attention, inhibitory control, and arousal regulation in fmr1 mutant mice: a model of Fragile X syndrome. Behav Neurosci. 2006
Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer’s disease. Behav Neurosci. 2004
저서/역서/편서
[특허]
줄기세포를 이용한 노화 조절 유효인자 구축 방법, 및 그를 이용하여 노화 조절 물질을 스크리닝 하는 방법, 및 그에 의해 도출된 항노화 물질. 2018.12.31. PCT 출원 (PCT/KR2018/016978)
노화 및 항노화 바이오마커 및 그의 용도. 2018.09.27. 국내출원 (10-2018-0115352)
인간 신경전구세포의 도파민 뉴우런으로의 분화방법 및 분화용 배지. 2018.09.04. 캐나다 등록 (2802661)
줄기세포를 이용한 노화 조절 유효인자 구축 방법, 및 그를 이용하여 노화 조절 물질을 스크리닝 하는 방법, 및 그에 의해 도출된 항노화 물질. 2017.12.29. 국내 출원 (10-2017-0184815)
C3 또는 C1r 보체를 분비하는 태반 유래 중간엽 줄기세포 및 이를 포함하는 조성물. 2017.12.07. 국내 등록 (10-1808762)
신경 전구 세포의 증식 방법 및 증식된 신경 전구 세포를 포함하는 신경 질환 치료용 조성물. 2017.04.10. 미국 출원 (15/518,184)
신경 전구 세포의 증식 방법 및 증식된 신경 전구 세포를 포함하는 신경 질환 치료용 조성물. 2017.04.10. 유럽 출원 (14903548.7)
신경 전구 세포의 증식 방법 및 증식된 신경 전구 세포를 포함하는 신경 질환 치료용 조성물. 2016.09.28. 국내 등록 (10-1662792)
인간 신경전구세포의 도파민 뉴우런으로의 분화방법 및 분화용 배지. 2016.03.07. 호주 등록 (2011265956)
C3 또는 C1r 보체를 분비하는 태반 유래 중간엽 줄기세포 및 이를 포함하는 조성물. 2015.10.29. PCT 출원 (PCT/KR2015/011493)
태반 유래 중간엽 줄기 세포, 또는 태반 유래 줄기세포로부터 유도된 신경 전구세포, 이를 포함하는 약학적 조성물, 질환 치료용 키트, 및 이를 이용하는 질환 치료방법. 2015.09.21. 국내등록 (10-1555981)
인간 신경전구세포의 도파민 뉴우런으로의 분화방법 및 분화용 배지. 2015.07.17. 일본 등록 (5776101)
인간 신경전구세포의 도파민 뉴우런으로의 분화방법 및 분화용 배지. 2015.01.07. 유럽 등록 (2581443)
인간 신경전구세포의 도파민 뉴우런으로의 분화방법 및 분화용 배지. 2014.12.30. 미국 등록 (8921107)
인간 신경전구세포의 도파민 뉴우런으로의 분화방법 및 분화용 배지. 2014.11.05. 중국 등록 (102985535)
C3 또는 C1r 보체를 분비하는 태반 유래 중간엽 줄기세포 및 이를 포함하는 조성물. 2014.10.29. 국내 출원 (10-2014-0148457)
신경 전구 세포의 증식 방법 및 증식된 신경 전구 세포를 포함하는 신경 질환 치료용 조성물. 2014.10.10. PCT 출원 (PCT/KR2014/009501)
신경 전구 세포의 증식 방법 및 증식된 신경 전구 세포를 포함하는 신경 질환 치료용 조성물. 2013.05.01 국내 출원 (10-2013-0049047)