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Dae-Seog Lim

Dae-Seog Lim

전공Cellular Immunity
연락처 031-881-7122 dslim@cha.ac.kr

학력

  • 1988~1992 건국대학교 축산학 학사
  • 1992~1994 건국대학교 대학원 생물공학 석사
  • 1995~2003 건국대학교 대학원 생물공학 박사

경력

  • 2019(3)~현재 차 의과학대학교 일반대학원 부원장
  • 2015~현재 차 의과학대학교 바이오공학과 부교수
  • 2014(03)~2016(02) 차 의과학대학교 바이오공학과 학과장
  • 2009~2015 차 의과학대학교 바이오공학과/약학과 조교수
  • 2005~2009 중외신약 크레아젠㈜ 수석연구원
  • 2003~2005 ㈜두산 선임연구원

    • [학회활동]
  • 대한면역학회
  • 수지상세포연구회

논문

    [주요연구 내용]
  • 수지상세포를 이용한 류마티스관절염 및 심혈관계 질환 등의 자가면역질환 치료 연구
  • 수지상세포의 분화 및 subset 마커 연구
  • 수지상세포 등을 포함하는 면역세포치료제의 항암연구
  • 미래부 바이오의료기술개발사업(총괄책임), 교과부 기초연구사업(책임), 보복부 글로벌코스메틱사업 연구(세부책임) 등 수행 중

    • [국외논문(recently)]
  • Ji-Soo Oh, Sung-Uk Hwang, Kyung-Eun Noh, Jun-Ho Lee, So-Yeon Choi, Ji-Hee Nam, Min-Seon Song, Nam-Chul Jung, Jie-Young Song, Han Geuk Seo, Younghwa Na, Dae-Seog Lim(Corr. Author). Synthetic TGF-b signaling agonist-treated dendritic cells induce tolerogenicity and antirheumatic effects. Current Issues in Molecular Biology. 2022. 44(9):3809-3821.
  • Ji-Hee Nam, Jun-Ho Lee, Hyun-Ji Choi, So-Yeon Choi, Kyung-Eun Noh, Nam-Chul Jung, Jie-Young Song, Jinjung Choi, Han Geuk Seo, Sang Youn Jung, Dae-Seog Lim(Corr. Author). TNF-alpha Induces Mitophagy in Rheumatoid Arthritis Synovial Fibroblasts, and Mitophagy Inhibition Alleviates Synovitis in Collagen Antibody-Induced Arthritis. International Journal of Molecular Sciences. 2022. 23(10):5650.
  • Jeong-In Park, Kyung-Hee Song, Seong-Mook Kang, Jeeyong Lee, Seong-Jun Cho, Hyun Kyung Choi, Jiyeon Ahn, Jong-Kuk Park, Jaesung Kim, Sang-Gu Hwang, Dae-Seog Lim, Joon Kim, Seung-Youn Jung, Jie-Young Song. BHMPS inhibits breast cancer migration and invasion by disrupting Rab27a-mediated EGFR and fibronectin secretion. Cancers. 2022. 14(2):373.
  • Jun-Ho Lee, So-Yeon Choi, Soo-Yeoun Park, Nam-Chul Jung, Kyung-Eun Noh, Ji-Hee Nam, Ji-Soo Oh, Hyun-Ji Choi, Ji-Su Jang, Ji-Young Yoo, Jie-Young Song, Han Geuk Seo, Dae-Seog Lim(Corr. Author). Enpp2 expression by dendritic cells is a key regulator in migration. Biomedicines. 2021. 9(11):1727.
  • Kyung-Eun Noh, Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, JI-Hee Nam, Ji-Soo Oh, Jie-Young Song, Han Geuk Seo, Yu Wang, Hyun Soo Lee, Dae-Seog Lim(Corr. Author). TGF-b/IL-7 chimeric switch receptor-expressing CAR-T cells inhibit recurrence of CD19-positive B cell lymphoma. International Journal of Molecular Sciences. 2021. 22(16):8706.
  • Jung-Seok Hwang, Jinwoo Hur, Won Jin Lee, Jun Pil Won, Hyuk Gyoon Lee, Dae-Seog Lim, Eunsu Kim, Han Geuk Seo. Catalase mediates the inhibitory actions of PPARdelta against angiotensin II-triggered hypertrophy in H9c2 cardiomyocytes. Antioxidants. 2021. 10(8):1223.
  • Jun-Ho Lee, So-Yeon Choi, Soo-Yeoun Park, Nam-Chul Jung, Ji-Soo Oh, Jinjung Choi, Ji Hyung Chung, Jie-Young Song, Han Geuk Seo, Dae-Seog Lim(Corr. Author). Keratinocyte conjugation by adhesion peptide induces up-regulation of tight junction proteins and immune regulation under inflammatory conditions. Biomedical Journal of Scientific and Technical Research. 2021. 36(2):28324.
  • Ji-Hee Nam, Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Jie-Young Song, Han Geuk Seo, Dae-Seog Lim(Corr. Author). Functional ambivalence of dendritic cells: Tolerogenicity and Immunogenicity. International Journal of Molecular Sciences. 2021. 22(9):4430.
  • Sung-Won Park, Hyun-Jin Do, Wonbin Choi, Dae-Seog Lim, Keun-Hong Park, Jae-Hwan Kim. Epithelium-specific ETS transcription factor-1 regulates NANOG expression and inhibits NANOG-induced proliferation of human embryonic carcinoma cells. Biochimie. 2021. 186:33-42.
  • Sung-Uk Hwang, Jun-Ho Lee, So-Yeon Choi, Young-Tae Lee, Soo-Yeoun Park, Hyun Soo Lee, Jung-Wook Jae, Nam-Chul Jung, Wang Yu, Dae-Seog Lim(Corr. Author). A simple and efficient method of generating HCMV pp65-specific T cells using overlapping peptides. Acta Virologica. 2020. 64(4):470-479.
  • Heeyoung Lee, Soomin Lee, Sejeong Kim, Jeeyeon Lee, Jimyeong Ha, Yukyung Choi, Hyemin Oh, Yujin Kim, Yewon Lee, Dae-Seog Lim, Saehun Kim, Young Sil Han, Kyoung-Hee Choi, Yohan Yoon. Asymptomatic Clostridium perfringens inhabitation in intestine can cause inflammation, apoptosis, and disorders in brain. Foodborne Pathogens and Disease. 2020. 17(1):52-65.
  • Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Jie-Young Song, Han Geuk Seo, Hyun Soo Lee, Dae-Seog Lim(Corr. Author). The effect of the tumor microenvironment and tumor-derived metabolites on dendritic cell function. Journal of Cancer. 2020. 11(4):769-775
  • Won Jin Lee, Sun Ah Ham, Gyeong Hee Lee, Mi-Jung Choi, Hyunjin Yoo, Kyung Shin Paek, Dae-Seog Lim, Kwonho Hong, Jung Seok Hwang, Han Geuk Seo. Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner. Journal of Neurochemistry. 2019. 151(3):370-385.
  • Ji-Young Yoo, Nam-Chul Jung, Jun-Ho Lee, So-Yeon Choi, Hyun-Ji Choi, Soo-Yeoun Park, Ji-Su Jang, Sei-Hee Byun, Sung-Uk Hwang, Kyung-Eun Noh, Yunok Park, Jongwon Lee, Jie-Young Song, Han Geuk Seo, Hyun Soo Lee, Dae-Seog Lim(Corr. Author). Pdlim4 is essential for CCR7-JNK-mediated dendritic cell migration and F- actin-related dendrite formation. FASEB Journal. 2019. 33(10):11035-11044
  • Sang Youn Jung, Kil-Sang Cho, Doo-Rye Jang, Jun-Ho Lee, So-Yeon Choi, Sei-Hee Byun, Soo-Yeoun Park, Nam-Chul Jung, Jinjung Choi, Kwang-Hoe Chung, Jin-Ah Jang, Jun-Eui Park, Hyun Soo Lee, Dae-Seog Lim(Corr. Author). Synergistic effect of tolerogenic dendritic cells and etanercept on a collagen-induced arthritis animal model. Journal of Hard Tissue Biology. 2019. 28(3):265-272.
  • Jung Seok Hwang, Won Jin Lee, Jinwoo Hur, Hyuk Gyoon Lee, Eunsu Kim, Gyeong Hee Lee, Mi-Jung Choi, Dae-Seog Lim, Kyung Shin Paek, Han Geuk Seo. Rosiglitazone-dependent dissociation of HuR from PPAR-r regulates adiponectin expression at the posttranscriptional level. FASEB Journal. 2019. 33(6):7707-7720.
  • Eun Sil Kang, Jung Seok Hwang, Won Jin Lee, Gyeong Hee Lee, Mi-Jung Choi, Kyung Shin Paek, Dae-Seog Lim, Han Geuk Seo. Ligand-activated PPARdelta inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS. PLOS One. 2019. 14(1):e0210482.
  • Ji-Su Jang, Jun-Ho Lee, Nam-Chul Jung, So-Yeon Choi, Soo-Yeoun Park, Ji-Young Yoo, Jie-Young Song, Han Geuk Seo, Hyun Soo Lee, Dae-Seog Lim(Corr. Author). Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway. Cell Death and Disease. 2018. 9:823.
  • Won Jin Lee, Sun Ah Ham, Hyunjin Yoo, Jung Seok Hwang, Taesik Yoo, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Kwonho Hong, Han Geuk Seo. Activation of PPARdelta attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. Journal of Cellular Biochemistry. 2018. 119(7):5609-5619.
  • Nam-Chul Jung, Jun-Ho Lee, Kwang-Hoe Chung, Yi Sub Kwak, Dae-Seog Lim(Corr. Author). Dendritic cell-based immunotherapy for solid tumors. Translational Oncology. 2018. 11(3):686-690.
  • Min Young Ahn, Sun Ah Ham, Taesik Yoo, Won Jin Lee, Jung Seok Hwang, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Han Geuk Seo. Ligand-Activated Peroxisome Proliferator-Activated Receptor delta Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression. Journal of Vascular Research. 2018. 55(2):75-86.
  • Jung Seok Hwang, Eun Sil Kang, Sung Gu Han, Dae-Soeg Lim, Kyung Shin Paek, Chi-Ho Lee and Han Geuk Seo. Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPAR-delta-dependent manner. PeerJ. 2018. 6:e4208.
  • Kiyuk Chang, Jie-Young Song, Dae-Seog Lim(Corr. Author). Tolerogenic dendritic cell-based immunotherapy. Oncotarget. 2017. 8(53):90630-90631.
  • Sun Ah Ham, Taesik Yoo, Won Jin Lee, Jung Seok Hwang, Jinwoo Hur, Kyung Shin Paek, Dae-Seog Lim, Sung Gu Han, Chi-Ho Lee, Han Geuk Seo. ADAMTS1-mediated targeting of TSP-1 by PPARdelta suppresses migration and invasion of breast cancer cells. Oncotarget. 2017. 8(55):94091-94103.
  • Eun Ho Choo, Jun-Ho Lee, Eun-Hye Park, Hyo Eun Park, Nam-Chul Jung, Tae-Hoon Kim, Yoon-Seok Koh, Eunmin Kim, Ki-Bae Seung, Cheongsoo Park, Kwan-Soo Hong, Kwonyoon Kang, Jie-Young Song, Han Geuk Seo, Dae-Seog Lim(Corr. Author), Kiyuk Chang. Infarcted Myocardium-Primed Dendritic Cells Improve Remodeling and Cardiac Function After Myocardial Infarction by Modulating the Regulatory T Cell and Macrophage Polarization. Circulation. 2017. 135(15):1444-1457.
  • Sei-Hee Byun, Jun-Ho Lee, Nam-Chul Jung, Hyun-Ji Choi, Jie-Young Song, Han Geuk Seo, Jinjung Choi, Sang Youn Jung, Sangjin Kang, Yong-Soo Choi, Ji Hyung Chung, Dae-Seog Lim(Corr. Author). Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice. Biochemical Pharmacology. 2016. 115:85-93.
  • Nam-Chul Jung, Jun-Ho Lee, Hyun-Ji Choi, Sung-Uk Hwang, Jie-Young Song, Han Geuk Seo, Jinjung Choi, Sang Youn Jung, Sung Gu Han, Dae-Seog Lim(Corr. Author). Dendritic cell immunotherapy combined with cytokine-induced killer cells effectively suppresses established hepatocellular carcinomas in mice. Immunological Investigations. 2016. 45(6):553-565.
  • Kyung-Hee Song, Seung-Youn Jung, Seong-Mook Kang, Mi-Hyoung Kim, Jiyeon Ahn, Sang-Gu Hwang, Jun-Ho Lee, Dae-Seog Lim(Corr. Author), Seon Young Nam, Jie-Young Song. Induction of immunogenic cell death by radiation-upregulated karyopherin alpha 2 in vitro. Europaen Journal of Cell Biology. 2016. 95(6-7):219-227.
  • Eun Gae Lee, Nam-Chul Jung, Jun-Ho Lee, Jie-Young Song, Sang-Young Ryu, Han Geuk Seo, Sung Gu Han, Keun Jae Ahn, Kwan Soo Hong, Jinjung Choi, Dae-Seog Lim(Corr. Author). Tolerogenic dendritic cells show gene expression profiles that are different from those of immunogenic dendritic cells in DBA/1 mice. Autoimmunity. 2016. 49(2):90-101.
  • Sukyung Kang, Jae Sung Lee, Hai Chon Lee, Michael C. Petriello, Bae Yong Kim, Jeong Tae Do, Dae-Seog Lim, Hong Gu Lee, Sung Gu Han. Phytoncide extracted from pinecone dereases LPS-induced inflammatory responses in bovine mammary epithelial cells. J. Microbiol Biotechnol. 2016. 26(3):579-587.
  • J-Y Song, D-S Lim(Corr. Author). Radiation-induced gamma-synuclein in regards to DC function. Cell Death Disease. 2015. 6:e1883. E-pub.
  • Jung Seok Hwang, So Young Eun, Sun Ah Ham, Taesik Yoo, Won Jin Lee, Kyung Shin Paek, Jeong Tae Do, Dae-Seog Lim, Han Geuk Seo. PPAR-delta modulates oxLDL-induced apoptosis of vascular smooth muscle cells through a TGF-beta/FAK signaling axis. International Journal of Biochemistry and Cell Biology. 2015. 62:54-61.
  • S-M Kang, M-H Kim, K-H Song, S-Y Jung, J Ahn, S-G Hwang, J-H Lee, D-S Lim(Corr. Author), J-Y Song. Modulation of dendritic cell function by the radiation-mediated secretory protein gamma-synuclein. Cell Death Discovery. 2015. 1:e15011. E-pub.
  • Shin Hee Hong, Jin Gu Cho, Kang Jun Yoon, Dae-Seog Lim, Chul Hoon Kim, Sang-Won Lee, Sang Gyu Park. The antibody atliximab attenuates collagen-induced arthritis by neutralizing AIMP1, an inflammatory cytokine that enhances osteoclastogenesis. Biomaterials. 2015. 44:45-54.
  • Mi-Hyoung Kim, Seung-Youn Jung, Jiyeon Ahn, Sang-Gu Hwang, Hee-Jong Woo, Sungkwan An, Seon Young Nam, Dae-Seog Lim, Jie-Young Song. Quantitative proteomic analysis of single or fractionated radiation-induced proteins in human breast cancer MDA-MB-231 cells. Cell and Bioscience. 2015. 5:2. E-Pub.
  • Sun Ah Ham, Taesik Yoo, Jung Seok Hwang, Eun Sil Kang, Won Jin Lee, Kyung Shin Paek, Chankyu Park, Jin-Hoi Kim, Jeong Tae Do, Dae-Seog Lim, Han Geuk Seo. Ligand-activated PPARdelta modulates the migration and invasion of melanoma cells by regulating Snail expression. Am J Cancer Res. 2014. 4(6):674-682.
  • Hwang JS, Lee WJ, Kang ES, Ham SA, Yoo T, Paek KS, Lim DS, Do JT, Seo HG. Ligand-activated peroxisome proliferator-activated receptor-delta and -gamma inhibit lipopolysaccharide-primed release of high mobility group box 1 through upreguation of SIRT1. Cell Death Dis. 2014. 5:e1432. E-pub.
  • Z-Hun Kim, Jung Wook Hwang, Joon Ho Lee, Hojin Kim, Dae-Seog Lim, Sangjin Kang, Heui Sam Lee, Yong-Soo Choi. Whitening effect of storage protein 2 from silkworm hemolymph. Advances in Bioscience and Biotechnology. 2014. 5:758-767.
  • Min Jin Lim, Jiyeon Ahn, Jae Youn Yi, Mi-Hyoung Kim, A-Rang Son, Sae-lo-oom Lee, Dae-Seog Lim, Sung Soo Kim, Mi Ae Kang, Youngsoo Han, Jie-Young Song. Induction of Galectin-a by TGF-beta1 accelerates fibrosis through enhancing nuclear retention of smad2. Exp Cell Res. 2014. 326(1):125-135.
  • Jun-Ho Lee, Tae-Hoon Kim, Hyo Eun Park, Eun Gae Lee, Nam-Chul Jung, Jie-Young Song, Han Geuk Seo, Ki-Bae Seung, Kiyuk Chang, Dae-Seog Lim(Corr. Author). Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis. Cardiovasc Res. 2014. 101(2):203-210.
  • Sun A. Ham, Eun S. Kang, Hanna Lee, Jung S. Hwang, Taesik Yoo, Kyung S. Paek, Chankyu Park, Jin-Hoi Kim, Dae-Seog Lim, Han G. Seo. PPARdelta inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling. J Invest Dermatol. 2013. 133(11):2593-2600.
  • Kyung-Sul Kim, Hyun Sook Kim, Ji-Min Park, Han Wool Kim, Mi-Kyung Park, Hyun-Seob Lee, Dae-Seog Lim, Tae Hee Lee, Michael Chopp, Jisook Moon. Long-term Immunomodulatory effect of amniotic stem cells in Alzheimer’s disease model. Neubiol Aging. 2013. 34(10):2408-2420.
  • Jung Seok Hwang, Eun Sil Kang, Sun Ah Ham, Taesik Yoo, Hanna Lee, Kyung Shin Paek, Chankyu Park, Jin-hoi Kim, Dae-Seog Lim, Han Geuk Seo. Activation of peroxisome proliferator-activated receptor release of high mobility group box 1. Mediat Inflamm. 2012. E-pub.
  • Min-Jin Lim, Ji-Yeon Ahn, Youngsoo Han, Chi-ho Yu, Mi-Hyoung Kim, Sae-lo-oom Lee, Dae-Seog Lim(Co-Corr. Author), Jie-Young Song. Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. Int J Biochem Cell B. 2012. 44(8):1214-1222.
  • Nam-Chul Jung, Hee Jung Kim, Mi-Sun Kang, Jun-Ho Lee, Jie-Young Song, Han Geuk Seo, Yong-Soo Bae, Dae-Seog Lim(Corr. Author). Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors. Cancer Lett. 2012. 324(1):58-65.
  • Hanna Lee, Sun Ah Ham, Min Young Kim, Jae-Hwan Kim, Kyung Shin Paek, Eun Sil Kang, Hyo Jung Kim, Jung Seok Hwang, Taesik Yoo, Chankyu Park, Jin-Hoi Kim, Dae-Seog Lim, Chang Woo Han, Han Geuk Seo. Activation of PPAR-delta counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells. Free Rad Res. 2012. 46(7):912-919.
  • Hana Jin, Sun Ah Ham, Min Young Kim, Im Sun Woo, Eun Sil Kang, Jung Seok Hwang, Ko-woon Lee, Hye Jung Kim, Gu Seob Roh, Dae-seog Lim, Dawon Kang, Han Geuk Seo. Activation of peroxisome proliferator-activated receptor delta attenuates glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. J Neuroscience Research. 2012. 90(8):1646-1653.
  • Choi YS, Dae-Seog Lim(Co-first), Kim DI. Effects of mixed feeder cells on the expansion of CD34+ cells. J Bioscience Bioengineering. 2012. 113(3):389-394.
  • Park SJ, Lee KW, Dae-Seog Lim, Lee S. The sulfated polysaccharide fucoidan stimulates osteogenic differentiation of human adipose-derived stem cells. Stem Cells Dev. 2012. 21(12):2204-2211.
  • Yong-Soo Choi, Ju-Ah Jeong, Dae-Seog Lim(Corr. Author). Mesenchymal stem cell-mediated immature dendritic cells induce regulatory T cell-based immunosuppressive effect. Immunol Invest. 2012. 41(2):214-229.
  • Dae-Seog Lim(Corr. Author), Yong-Soo Bae. Metastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis. Rheumatol Int. 2011. 31(7):843-847.
  • Dae-Seog Lim, Mi-Sun Kang, Ju-Ah Jeong, Yong-Soo Bae. Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice. Eur J Immunol. 2009. 39:1334-1343.
  • Cheol-Hee Yoon, Eun-Soo Lee, Dae-Seog Lim, Yong-Soo Bae. PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Proc Natl Acad Sci USA. 2009. 106:7852-7857.

    • [국내논문]
  • 김미형, 유상영, 임대석, 송지영. 마우스에서 전신 저선량 분할 방사선 조사에 의한 면역학적 변화 평가. 방사선방어학회지. 2014. 39(3):134-141.
  • 이준호, 정남철, 이은계, 임대석(교신저자). Near-infrared (NIR) 영상기법을 이용한 생체 내 수지상세포의 이동. 한국생물공학회지. 2012. 27(5):295-300.
  • 박수정, 이교원, 임대석, 이수만. 지방조직 유래 중간엽 줄기세포의 세포군별 분리. 대한화상학회지. 2012. 14(2):93-96.

저서/역서/편서

  • Ji-Hee Nam, Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Dae-Seog Lim. Prime Archives in Molecular Sciences: 2nd Edition (Chapter: Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity). VIDE LEAF. 18th Aug. 2021. ISBN 978-81-953047-1-4.
  • Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Dae-Seog Lim. Prime Archives in Cancer Research (Chapter: The Effect of the Tumor Microenvironment and Tumor-Derived Metabolites on Dendritic Cell Function. VIDE LEAF. 19th Oct. 2020. ISBN 978-81-944664-4-4.
  • Dae-Seog Lim, Jun-Ho Lee, Sei-Hee Byun. Dendritic cells for the treatment of autoimmune disease (Rheumatoid arthritis). Lambert Academic Publishing. 20th Sep. 2016. ISBN 978-3-659-95485-6.

    • [국내외 특허]
  • Clec5a 발현 면역관용 수지상세포 또는 그의 배양물을 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 : 2021년7월23일, 대한민국 특허출원 10-2021-0097188
  • 수지상세포의 TGF-beta 수용체 활성화용 조성물 및 이를 이용한 자가면역질환의 예방 또는 치료 방법 : 2021년5월13일, 대한민국 특허출원 제21-62149호
  • 수지상세포의 성숙도 측정 방법 및 조성물, 그리고 이의 용도 : 2019년 4월11일, 대한민국 특허출원 제19-42741호 : 2020년11월27일, 대한민국 특허등록 제10-2186534호
  • CD19 키메라 항원 수용체 및 절단된 TGFBRII를 발현하는 재조합 면역 세포 및 이의 용도 : 2018년 12월11일, 대한민국 특허출원 10-2018-0159376
  • 수지상세포의 이동능을 증가시키는 방법 및 이의 용도 : 2018년5월4일, 대한민국 특허출원 제18-52135호 : 2019년1월28일, 국제 PCT 출원 PCT/KR2019/001173 : 2020년3월16일, 대한민국 특허등록 제 10-2091748호 : 2020년9월1일, 미국 특허 출원 16/977,320 (Method for increasing dendritic cell migration ability, and use thereof)
  • 성숙 수지상 세포 검출용 바이오마커 및 이의 용도 : 2017년 8월 31일. 대한민국 특허출원 제17-111045호 : 2021년 4월1일, 대한민국 특허등록 제 10-2237527호
  • 면역관용 수지상세포 확인용 마커 및 이의 용도 : 2014년 4월30일, 대한민국 특허출원 10-2014-0052952 : 2016년 7월22일, 대한민국 특허등록 제 10-1643716호
  • 겔솔린을 유효성분으로 포함하는 수지상세포 분화 유도용 조성물 및 이의 분화 유도방법 : 2014년 1월8일, 대한민국 특허출원 10-2014-0002282 : 2015년 11월5일, 대한민국 특허등록 제 10-1568323호
  • 면역관용 수지상세포를 제조하는 방법 및 이를 통해 제조된 면역관용 수지상세포 : 2013년 11월15일, 대한민국 특허출원 10-2013-0138873 : 2016년 4월12일, 대한민국 특허등록 제 10-1613675호
  • 심근경색 치료용 면역관용 수지상세포 및 그 제조방법 : 2014년 4월2일, 대한민국 특허출원 10-2014-0039223 : 2014년 10월7일, 미국 특허출원 14/508,842 : 2016년 6월1일, 대한민국 특허등록 제 10-1628453호
  • 마이오신을 이용하여 제조된 면역관용 수지상세포 및 이의 제조 방법 : 2011년 12월6일, 대한민국 특허출원 10-2011-0129807 : 2014년 2월13일, 대한민국 특허등록 제 10-1365207호
  • 바이러스를 이용하여 제조된 심근염 치료용 면역관용 수지상세포 및 이의 제조 방법 : 2011년 12월6일, 대한민국 특허출원 10-2011-0129808 : 2014년 2월13일, 대한민국 특허등록 제 10-1365208호
  • 활성화된 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물 : 2011년 5월4일, PCT 특허출원 PCT/KR2011/003331
  • 골질환의 예방 또는 치료용 약학 조성물 및 중간엽 줄기세포의 골아세포로의 분화방법 : 2011년 2월18일, 대한민국 특허출원 10-2011-0014329
  • 암세포로의 표적지향을 위한 자연살해세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물 : 2013년 8월13일, 대한민국 특허등록 제 1298012호
  • 활성화된 자연살해세포를 포함하는 림프구의 제조방법 : 2010년 3월23일, 대한민국 특허출원 10-2010-0025574
  • MLN51 유전자 또는 단백질의 신규한 용도 : 2008년 4월 8일. 대한민국 특허등록 10-0822181 : 2013년 8월 20일. 미국 특허등록 US 8,513,028 B2
  • 면역억제능이 증가된 간엽줄기세포-매개 자가유래 수지상세포. : 2007년 2월 22일. 대한민국 특허출원 10-2008-0117836. : 2007년 7월 31일. PCT출원 PCT/KR2007003681.
  • 준성숙 수지상세포를 포함하는 류마티스 관절염 치료용 약제학적 조성물. : 2009년 3월 2일. 대한민국 특허등록 10-0887560. : 2008년 3월 12일. PCT출원 PCT/KR2008/001397.
  • 종양성장 억제능을 갖는 광역동성 치료 매개 자가유래 수지상세포. : 2010년 4월15일. 대한민국 특허등록 제 0954315호. : 2008년 7월 9일. PCT출원 PCT/KR2008/004042.
  • 모노메틸파이토스핑고신-폴리에틸렌글리콜 및 그를 함유하는 항암 조성물. : 2007년 6월 29일. 대한민국 특허등록 0736145.
  • 모노메틸파이토스핑고신 및 그를 함유하는 항암 조성물. : 2007년 4월 2일. 대한민국 특허등록 0705054.
  • 포스포리피드를 함유하는 단백질 티로신 포스파타제 1비 억제제 및 이를 이용한 당뇨병, 비만예방 및 치료용 조성물. : 2004년 11월 23일. 대한민국 특허출원 10-2004-0096446. : 2006년 5월 26일. 대한민국 특허공개 10-2006-0057337.
  • 신규 스핑고리피드 유도체 및 그를 함유하는 항암 조성물. : 2004년 7월 1일. 대한민국 특허출원 2004-0051250.

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